Sep 2026
Abstract A111: Understanding the interplay between ULK1/2 signaling and the RAS MAPK pathway
Pancreatic ductal adenocarcinoma (PDAC) is dependent on mutant KRAS and elevated autophagy for growth. Previously, we and others demonstrated that pharmacological inhibition of the KRAS ERK-MAPK pathway caused increased autophagic flux. Targeting this increased autophagic flux with inhibitors that block autophagic pr...
Seamus E. Degan, Mallory K. Roach, Jonathan M. DeLiberty et al.
· Cancer Research · 0 citations