Nuclear localized p70S6K maintain cancer stem-like properties by modulating RPA3 activity in osteosarcoma.
Cancer stem-like cells (CSCs) are believed to be a pivotal contributor to therapy failure in various cancers including osteosarcoma. Targeting CSCs is a promising strategy to overcome chemoresistance and improve outcomes in osteosarcoma treatment. Besides the conventionally studied cytoplasmic p70 ribosomal protein S6...