Author

Lin Han

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Open access Sep 2026

Screening for medicine and food homologous ingredients targeting ALDH2 to alleviate acute ethanol-induced liver injury

Background Alcoholic liver disease (ALD) is a major global health burden with limited therapeutic options. Aldehyde dehydrogenase 2 (ALDH2) plays a critical role in alcohol metabolism, and ALDH2 deficiency exacerbates alcohol-induced hepatic injury. Aim This study aimed to identify and validate natural ALDH2 activators...

Yuan Lu, Zi-Bin Li, Pan Gao et al. · Frontiers in Nutrition · 0 citations

Open access Sep 2026

Ligand Fishing for Xanthine Oxidase Inhibitors From Brassica rapa L. via Bioaffinity Ultrafiltration‐HPLC‐MS/MS: Mechanistic Insights and In Vitro Anti‐Hyperuricemic Activity

Hyperuricemia is a prevalent metabolic disorder arising from dysregulated purine metabolism, wherein xanthine oxidase (XOD) serves as the key rate‑limiting enzyme catalyzing the final oxidation of hypoxanthine and xanthine to uric acid. Although Brassica rapa L. (chamagu) has been previously reported to exert ant...

Xuan-Bo Chen, Hai-Yu Wu, Zi-Wei Guo et al. · Food Frontiers · 0 citations

Sep 2026

A Non-canonical role of phloretin in renal protection: Targeting WNT2B downregulation to prime PINK1/ PARKIN-dependent mitophagy and attenuate renal fibrosis.

Renal fibrosis, the common pathological endpoint of diverse kidney injuries, drives the progression to end-stage kidney disease. Its rising prevalence, mirroring the global chronic kidney disease burden, starkly contrasts with the unmet need for safe and effective therapies. Fibrogenesis is centrally driven by transfor...

Xue Wu, Yong-Hui Dong, Jia Li et al. · Phytomedicine · 0 citations