Review
Open access
Sep 2026
HDAC3-driven immunometabolic reprogramming in type 2 diabetes and its complications: from enzymatic deacetylation to non-enzymatic scaffolding
This review comprehensively integrates the regulatory mechanisms of HDAC3 in β-cell dysfunction, insulin resistance, mitochondrial impairment, and chronic inflammation, highlighting its pivotal role in the initiation and progression of T2DM.
Nian-Xin Kang, Qi-Qi Zhang, Xiang-Yuan Zhang et al.
· Frontiers in Immunology · 0 citations