Integrated reverse network toxicology and experimental validation identify PTP4A3 as a key target of Benzo[a]pyrene in prostate cancer.
Prostate cancer (PCa), a leading cause of cancer morbidity in males globally, is closely related to genetic susceptibility and environmental exposure, which is difficult to clarify by traditional methods. To elucidate this mechanism, we adopted an integrated strategy that combined multi-omics profiling. By integrating...