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Lin-Jie Guo

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Review Aug 2026

DNA Framework Nanomachines for Translational Medicine

It is proposed that topical drug delivery based on DNA frameworks is approaching clinical translation, and intelligent DNA framework nanomachines may implement automated, adaptive, multidimensional theranostics, advancing the vision of precision medicine.

Lixuan Lin, Kai Jiao, Lin-Jie Guo et al. · 0 citations
Review Jul 2026

Innate Immunity of Framework Nucleic Acids.

This Account reviews efforts to develop framework nucleic acids (FNAs) as a platform with modulable innate immunostimulation for biomedical applications in live cells and in vivo, and envision FNAs as intelligent tools for precision immunomodulation, bridging nanoscale design with immunological outcomes to advance pers...

Lin-Jie Guo, Fei Zhou, Ying Zhu et al. · 0 citations
Open access Jul 2026

Direct Cytosolic Delivery of Amphiphilic Framework Nucleic Acids for RNA Interference.

A class of amphiphilic framework nucleic acids (ampFNAs) that enable direct cytosolic delivery involving energy-independent traversal of lipid membranes and establishes ampFNAs as a programmable, efficient, and biocompatible platform for the development of next‑generation smart nucleic acid delivery machines for precis...

Lixuan Lin, Kai Jiao, Biancheng Wei et al. · 0 citations

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