It is proposed that topical drug delivery based on DNA frameworks is approaching clinical translation, and intelligent DNA framework nanomachines may implement automated, adaptive, multidimensional theranostics, advancing the vision of precision medicine.
Lixuan Lin, Kai Jiao, Lin-Jie Guo et al.· Accounts of Materials Resear...· 0 citations
This Account reviews efforts to develop framework nucleic acids (FNAs) as a platform with modulable innate immunostimulation for biomedical applications in live cells and in vivo, and envision FNAs as intelligent tools for precision immunomodulation, bridging nanoscale design with immunological outcomes to advance pers...
Lin-Jie Guo, Fei Zhou, Ying Zhu et al.· Accounts of Chemical Researc...· 0 citations
A class of amphiphilic framework nucleic acids (ampFNAs) that enable direct cytosolic delivery involving energy-independent traversal of lipid membranes and establishes ampFNAs as a programmable, efficient, and biocompatible platform for the development of next‑generation smart nucleic acid delivery machines for precis...
Lixuan Lin, Kai Jiao, Biancheng Wei et al.· Angewandte Chemie· 0 citations
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