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Lin-Lin Zhang

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Open access Sep 2026

Development and validation of an interpretable machine learning model for predicting chemotherapy-induced neutropenia in small cell lung cancer: a web-based clinical decision support tool

Objective To develop and validate an interpretable machine learning model for predicting grade ≥3 chemotherapy-induced neutropenia (CIN) in patients with small cell lung cancer (SCLC), and to establish a web-based clinical decision support tool for individualized risk assessment. Methods We conducted a retrospective ob...

Jing-Yue Zhang, Si-Yu Lu, Chang Liu et al. · 0 citations
Open access Aug 2026

DNA Damage Response Alterations Stratify Response to ICI-Based Therapy in Advanced NSCLC with High PD-L1 Expression

Background: Although high PD-L1 expression correlates with improved outcomes to immune checkpoint inhibitor (ICI), it remains an imperfect predictive biomarker. DNA damage response (DDR) pathway alterations are closely associated with antitumor immunity, shaping tumor immunogenicity and the immune microenvironment. Thi...

Fang Hao, Lin-Lin Zhang, Dian-Sheng Zhong · 0 citations

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