Author

Linling He

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Open access Oct 2026

Xenoglycosylation of the HIV-1 Glycan Shield Promotes Cross-Clade Neutralization and Diverse Human Antibody Lineages

Despite advances in HIV-1 envelope glycoprotein (Env)-based vaccine design, eliciting broadly neutralizing antibodies (bNAbs) remains a central challenge. Here, we identify core α(1,3)-fucose as a key modulator of neutralizing antibody (NAb) induction and breadth. Uncleaved prefusion-optimized (UFO) trimers and self-as...

Lin-Ling He, Xiao-He Lin, Yi-Nan Zhang et al. · bioRxiv · 0 citations

Open access Aug 2026

Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza vaccine development

Current influenza vaccines primarily target hemagglutinin (HA), the major viral surface glycoprotein and principal determinant of neutralizing antibody (NAb) responses. However, antigenic drift and shift, together with HA’s intrinsic metastability and low-pH sensitivity, limit broad and durable vaccine protection. Here...

Yi-Nan Zhang, Xue-Yong Zhu, Keegan Braz Gomes et al. · Nature Communications · 0 citations

Open access Aug 2026

The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages.

Describing the genetic, structural, functional, and epitope features of 25 BD-directed nAbs isolated from HCV-infected individuals or immunized macaques underscores BD as a promising target for rational HCV vaccine design.

Fang Chen, Yen Thi Kim Nguyen, Yi-Zong Lee et al. · Cell Reports · 0 citations