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Author

Lin Liu

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Aug 2026

Global transcriptional rewiring and dual-compartment engineering for efficient 3-hydroxypropionic acid production in Saccharomyces cerevisiae.

This work establishes a generalizable framework for multi-compartment malonyl-CoA utilization in eukaryotic cell factories through dynamic control of HFA1 and optimized POS5 expression, and develops a dual-compartment coordination strategy to efficiently exploit cytosolic and mitochondrial malonyl-CoA pools.

Jing Liu, Huiping Tan, Xi Deng et al. · 0 citations
Open access Aug 2026

A self-iterative orthogonal base-editing platform enables multiplex N-to-N diversification and genome-scale functional screening in Escherichia coli

MUTATOR is reported, a MUlTiplexAble and self-iTerative ORthogonal base-editing platform that enables N-to-N diversification in Escherichia coli and is established as a broadly applicable platform for genome-wide diversification, functional dissection, and rapid engineering of industrial microbial chassis.

Xiangrui Fan, Li-Ya Liang, Hongle Wang et al. · 0 citations

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