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Author

Lin-Qi Zhang

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Open access Oct 2026

Programmable design of functional RNAs through multimodal generative learning

RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative model that learns a conditionable design grammar from RNA sequences, experimental structural probing profiles, and functiona...

Jian-Bo Ma, Jiang-Hui Zhu, Wen-Ze Huang et al. · 0 citations
Sep 2026

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.

Study of individuals sequentially infected with SARS-CoV-1 and SARS-CoV-2 over two decades and found durable imprinting of antibody responses following SARS-2 BF.7 breakthrough infection defines the remarkable longevity and molecular basis of antibody imprinting and provides insights for pan-sarbecovirus vaccine design...

Qi Zhang, Peng Chen, Feng-Lin Guo et al. · 0 citations

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