Inflammatory diseases are characterized by overactivated immune responses and a disrupted metabolic equilibrium, particularly in dendritic cells (DCs), where mitochondrial reactive oxygen species (mtROS) burst and metabolic reprogramming drives pathological maturation. While modulating immunometabolism is a promising t...
OBJECTIVES
To overcome the intrinsic incompatibility between dense periodontal biofilms and chemodynamic therapy (CDT), we developed a vacancy-engineered MnO₂ nanozyme that integrates redox-state programming, Mg²⁺-enabled endogenous H₂O₂ amplification, and covalently immobilized quorum-sensing inhibition for the local...
This review examines COF-based aPDT from a structure-photophysics-ROS-biological response perspective and discusses the structural identity of COF-based platforms, core photodynamic mechanisms, photoactive building blocks, and enhancement strategies including metal coupling, targeting engineering, responsive release, p...
Ming-Can Zhao, Yuan-Dong Xie, Zhen-Yu Ma et al.· Wiley Interdisciplinary Revi...· 0 citations
This work comprehensively summarize the natural prototypes, design principles, and recent material advances in bioinspired targeting for aPDT, and conducts a comparative analysis of these strategies in terms of mechanisms, advantages, limitations, biosafety, and optimization pathways.
Xin-Yu Yu, Jing-Zhu Qu, Kun-Hao Li et al.· Materials Horizons· 0 citations
This strategy demonstrates that targeting intracellular energy vulnerabilities can achieve antibacterial, antibacterial, antibiofilm, and antivirulence effects against persistent infections.
