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Open access Aug 2026

Integrative multi-omics analysis reveals LLPS-associated CLEC2D⁺AR⁻ tumor-cell states linked to early adaptive progression toward castration resistance in prostate cancer

Findings provide a conceptual link between LLPS biology, AR-independent tumor-cell plasticity, and microenvironmental remodeling in CRPC, while nominating CLEC2D as a candidate marker and potential therapeutic target requiring further experimental validation.

Ze Cheng, Jinhua Yan, Shunkang Xue et al. · 0 citations

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