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Author

Lin-Xing Chen

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Open access Jan 2026

Unraveling the diversity, function, and virus–host interactions of archaeal proviruses

A systematic global genomic atlas of archaeal proviruses is established, advancing the understanding of their distribution and diversity while providing a foundation for future research into how proviruses regulate archaeal metabolism and ecosystem functioning.

Yang Zhao, Peng-Fei Liu, Lin-Xing Chen et al. · 0 citations
Open access Jul 2026

Structure and evolution-guided design of minimal RNA-guided nucleases

A protein design strategy is used that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs, establishing a strategy for creating non-natural RNA-guided nucleases and conformatio...

Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk et al. · 2 citations

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