Multi-omics integration identifies PON2 as a prognostic biomarker and mediator of tumor microenvironment remodeling in gallbladder cancer
Background Gallbladder cancer (GBC) is an aggressive biliary tract malignancy with limited therapeutic options and poor prognosis. Tumor microenvironment (TME) remodeling contributes substantially to GBC progression; however, the molecular drivers linking malignant epithelial programs to microenvironmental alterations...