MPTP-Induced D1R-Dependent Dysregulation of Ventral Hippocampal Newborn Cell Pools and Associated Alterations in the Hypothalamic–Pituitary–Adrenal Axis
Objective: This study investigated how dopaminergic (DAergic) depletion-induced ventral hippocampal neurogenesis triggers hypothalamic–pituitary–adrenal (HPA) axis hyperactivity. Methods: Three-month-old male C57BL/6 mice were subjected to systemic 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or ventral tegmenta...