Recent advances in spatial multi-omics have improved our ability to study tissue architecture, cellular heterogeneity, and cell-cell interactions within the tumor microenvironment. Xenium and Visium HD provide complementary strengths: Xenium offers true single-cell and subcellular spatial resolution but is limite...
Yang Liu, Akiko Sagara, Ji-Min Min et al.· Cancer Research· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) evolves within highly organized and dynamic tumor ecosystems in which malignant, stromal, and immune cell populations continuously interact in space. We conceptualize this spatial organization as a “cellular language,” where the identity, state, and spatial arrangement of indiv...
Purpose: SMARCB1-deficient renal medullary carcinoma (RMC) is an ultra-rare, lethal malignancy refractory to therapies approved for other renal cell carcinomas, and its rarity makes randomized trials logistically unfeasible. We investigated whether wild-type epidermal growth factor receptor (EGFR) is a therapeutically...
N. Zacharias, Eric S Rupe, Xinyue Chen et al.· Clinical Cancer Research· 0 citations
This study provides a comprehensive single-cell immune atlas of multiple myeloma and its precursors, offering insights into TME organization and progression, and may guide development of stage-specific or ecotype-targeted immunotherapies.
Ming-Hao Dang, Luz Yurany Moreno Rueda, Maria Jose Acevedo Calado et al.· Blood· 0 citations
Findings identify the BAX-SOX9-CDK4 axis as an important mechanism contributing to the antitumor activity of CYD-4-61 and provide a strong preclinical rationale for its further development as a therapeutic strategy for aggressive GAC.
Geng-Yi Zou, Katsuhiro Yoshimura, Yibo Fan et al.· Cancer Letters· 0 citations
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