Author

Ling-Jun Zhan

2 papers indexed here

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Review Open access Sep 2026

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Abstract Background Tuberculosis (TB), caused predominantly by Mycobacterium tuberculosis (Mtb), remains a major global health challenge despite the availability of antimicrobial chemotherapy. Drug‐resistant TB, latent infection, immunopathology and metabolic comorbidities such as diabetes continue to undermine treatme...

Jun-Fei Wang, Ying-Nan Zhou, Xun-Ming Ji et al. · Clinical and Translational M... · 0 citations

Open access Sep 2026

Transmembrane delivery of antimicrobial peptides by engineered eCIS into macrophages for intracellular mycobacteria elimination

Mycobacterium tuberculosis (M. tuberculosis, Mtb) is an intracellular bacterium persisting in macrophages, which can cause chronic infection and drug resistance. To address transmembrane limitation and improve treatment accuracy, we employed the Photorhabdus virulence cassette (PVC), a typical bacterial extracellular C...

Qi-Qi Wu, Rui-Wen Zhang, Mei-Yi Yan et al. · Science Advances · 0 citations