Paeonol alleviates oxidative stress and brain injury in hypoxic-ischemic encephalopathy by activating the PI3K/Akt/Nrf2 signaling pathway.
BACKGROUND Hypoxic-Ischemic Encephalopathy (HIE) is a severe neonatal neurological disorder, in which oxidative stress serves as a central mediator of brain injury. Paeonol (Pae), a phenolic compound with established anti-inflammatory and antioxidant properties, remains underexplored as a therapeutic strategy for HIE....