Author

Ling-Wen Ding

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Open access Sep 2026

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

Patients with inflammatory bowel disease (IBD) often exhibit gut microbiota dysbiosis and are predisposed to psychiatric disorders such as anxiety and depression. Consequently, developing novel oral probiotic therapies to address intestinal inflammation, microbiota dysbiosis, and psychiatric comorbidities is essent...

Qingling Song, Bei-Yang Xue, Yao Li et al. · BMEMat · 0 citations

Open access Aug 2026

Driver genomic lesions in MDM2, CDK4, and JUN co-opt targetable super-enhancer networks to impose liposarcomagenic core regulatory circuitry.

DDLPS-associated genomic lesions collaborate with BET-dependent chromatin regulation to establish disease-sustaining transcriptional circuitry, providing a mechanistic rationale for harnessing MDM2's E3 ligase activity to therapeutically degrade oncoproteins in MDM2-amplified malignancies.

Ye Chen, Ying Zhang, Long Xie et al. · Journal of Advanced Research · 0 citations

Review Open access Jul 2026

The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal

This review article provides a comprehensive overview of current mRNA development pipelines and ongoing clinical trials, and recent advances in mRNA purification techniques, focusing on strategies for dsRNA removal.

Jin-He Liu, Jian Zang, Jing-Ru Xu et al. · Journal of Biomedical Scienc... · 0 citations