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Author

Lingzhi Zhao

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Open access Jul 2026

Intranasal drop of multiplex RNA therapy for SARS-CoV-2 infections: baicalein-enhanced FEN1 nuclease cleaving as a virus buster

ABSTRACT Although the acute phase of the SARS-CoV-2 pandemic has subsided, viral persistence and variant evolution continue to challenge existing antiviral strategies. Here, we investigated an intranasal nanomedicine formulation comprising flap-endonuclease 1 (FEN1) and a panel of hairpin-structured DNA probes (hpDNAs)...

Jiyanuo Cao, Meng Wan, Jiayu Gu et al. · 0 citations
Review Jul 2026

Clinical Challenges in Echinococcosis Treatment and Frontiers in New Drug Development: Current Status and Future Outlook.

Echinococcosis, a zoonotic disease caused by larval Echinococcus tapeworms, manifests primarily as Cystic Echinococcosis (CE) and Alveolar Echinococcosis (AE). It poses a serious threat to the global livestock industry and public health. Based on a systematic review of the disease's epidemiological features, pathogen b...

Lin Wang, Zhengsheng Yan, Si Chen et al. · 0 citations
Aug 2026

Self-exploding tumor microenvironment-responsive nanomedicine as "ROS Bomb" ignites STING pathway for triple-negative breast cancer immunotherapy.

It is reported that horseradish peroxidase (HRP) can catalyze artemisinin to generate ROS, and a "ROS bomb" nanomedicine was designed for antitumor immunotherapy, offering a potent approach for treating deep-seated tumors.

Ke-Qiang Lu, Yaoquan Su, Xing-Chen Zhou et al. · 0 citations
Review Open access Jul 2026

Nanomedicine for Glioblastoma Therapy: Novel Insights and Future Perspectives.

This review systematically summarizes recent advances in nanomedicine enabled GBM therapy from four interrelated perspectives: the optimization of nanomaterial properties, the development of goal-oriented targeting strategies, the rationalization of delivery routes, and the engineering of smart stimuli-responsive nano-...

Yu Guo, Keqiang Lu, Wenmiao Luo et al. · 1 citation

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