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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Lingyi Kong

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2 papers indexed here

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Sep 2026

Targeting the nonenzymatic scaffold function of RIPK1 via a VHL-recruiting PROTAC synergizes with immunotherapy in melanoma.

Receptor-interacting protein kinase 1 (RIPK1) mediates cell survival, inflammation, and cell death, and its kinase-independent scaffolding function drives tumor progression and therapeutic resistance, which cannot be eliminated by conventional RIPK1 kinase inhibitors. To overcome this limitation, we adopted proteolysis...

Shun-Xin Guo, Ming-Ze Tang, Pei Yu et al. · 0 citations
Aug 2026

Lycorine alleviates intrahepatic cholestasis by regulating bile acid metabolism via TKT/ATF3/BSEP pathway.

Cholestatic liver disease (CLD) is defined by impaired bile synthesis and excretion, which in turn results in progressive liver injury or fibrosis, however, there are currently no effective therapeutic drugs. Lycorine is an alkaloid isolated from Lycoris bulbs, exhibiting antiviral, anti-inflammatory, analgesic, and ca...

Jiaman Liu, Ying Zheng, Yan-Qiu Zhang et al. · 0 citations

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