Case Report: Concomitant BRAF V600E and PIK3CA H1047R mutations in a micro-papillary thyroid carcinoma with extensive nodal metastasis
Although most papillary thyroid carcinoma (PTC) cases follow an indolent clinical course, a small subset presents with early extensive lymph node metastasis. Although this aggressive phenotype is frequently linked to the BRAF V600E mutation, concurrent activating mutations in the PI3K/AKT pathway, such as PIK3CA H1047R...