Author

Linsey Stiles

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Open access Sep 2026

The p53–p21–Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD

Aging drives chronic disease in part through senescent cells, including macrophages, which fuel inflammation. Senescent macrophages are functionally heterogeneous: canonical p16-high macrophages promote tumorigenesis or, in other contexts, disease tolerance, whereas we previously identified a distinct p21-high, p16-low...

Grasiela Torres, Ivan A. Salladay-Perez, Christina Y. Deng et al. · bioRxiv · 0 citations

Jul 2026

Abstract A077: Multi-pathway inhibition and synergistic anticancer activity of novel biguanides in triple negative breast cancer models

A novel treatment based on the biguanide metformin structure, termed JD006, which significantly inhibits TNBC cell growth in vitro and in vivo in a dose-dependent manner and at lower doses than its parental metformin, provides a strong preclinical rationale for combining next-generation biguanides with CDK4/6 inhibitor...

Julie Liu, Mario Morales Martinez, Eduardo Mauricio Gonzalez et al. · Clinical Cancer Research · 0 citations

Open access Jul 2026

Truncating ASXL1 variants rewire cellular metabolism via mitochondrial pyruvate carrier repression

A previously unrecognized chromatin-to-metabolism axis connecting gain-of-function ASXL1 truncation to mitochondrial pyruvate transport is defined, identifying MPC as a central mediator of epigenetic-metabolic crosstalk in both a rare developmental syndrome and ASXL1-mutant myeloid malignancy.

Isabella Lin, Michael Sigfrid S. Reyes, A. Krall et al. · bioRxiv · 0 citations