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Author

Linzhang Zhang

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Sep 2026

Tetramethylpyrazine ameliorates metabolic dysfunction-associated steatohepatitis by modulating gut microbiota dysbiosis and restoring intestinal barrier integrity.

BACKGROUND AND PURPOSE This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH). EXPERIMENTAL APPROACH Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...

Xiao-Li He, Linzhang Zhang, Ya-Di Zhu et al. · 0 citations
Aug 2026

Astragalus polysaccharides ameliorate irinotecan-induced gut toxicity by regulating gut microbiota and suppressing the MAPK signaling.

Findings suggest that APS, the key active fraction of AM against IGT, mitigate IGT by modulating microbiota-metabolite-MAPK axis, offering novel mechanistic insight for the ethnopharmacological use of AM to mitigate chemotherapy-induced intestinal toxicity.

Bolin Wu, Chenyang Zhou, Chu-Ting Xu et al. · 0 citations

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