Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarization and vascular smooth muscle cells (VSMCs) phenotypic switching are critical pathogenic events. Although G protein-coupled receptor 132 (GPR132) is markedly expressed in macrophages, its specific ro...
Yin Feng, Zheng Cao, Fan Zhang et al.· Inflammation Research· 0 citations
Background Heart failure (HF) after acute myocardial infarction (AMI) remains a major clinical challenge. The triglyceride glucose-waist-to-height ratio (TyG-WHtR) integrates metabolic and obesity indices, yet its prognostic value for AMI-HF is unclear. Methods This retrospective study enrolled 738 AMI patients undergo...
This work used isolated brain vascular fragments to study the blood–brain barrier and applied a combination of deep bulk proteomic analysis, a proteomic ruler approach, and scRNA-seq, assuming a high within-gene correlation between mRNA and protein.
Li-Qun He, Henrik J. Johansson, E. Vázquez-Liébanas et al.· Proceedings of the National...· 0 citations
It is shown that progerin leads to somatic mutation accumulation particularly in VSMCs, highlighting the need for early, cell-type-specific therapeutic intervention in HGPS to prevent permanent vascular tissue damage.
Lara G. Merino, Gwladys Revêchon, Santhilal Subhash et al.· Genome Medicine· 1 citation
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