Author

Lisa-Ann Gerdes

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Open access Nov 2026

Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase

The melastatin-like transient receptor potential channel, TRPM7, is crucial for signaling in leukocytes. It harbors a channel domain, permeable to divalent cations as well as a serine/threonine α-kinase, phosphorylating inter alia SMAD2. TRPM7 kinase activity is essential for the differentiation of non-pathogenic T hel...

Katharina Jacob, Anna S. Thomann, Anna Madlmayr et al. · bioRxiv · 0 citations

Aug 2026

Antibodies against MLC1 found in patients with NMOSD-like disease mediate astrocytopathy in rodent models.

MLC1 antibodies identify a subset of patients with an NMOSD-like phenotype, underscoring their potential as a disease marker with pathogenic relevance.

H. Wong, Samantha Ho, Qian Yu et al. · Science Translational Medici... · 0 citations