Open access
Aug 2026
A macrophage-intestinal organoid co-culture model captures balanced epithelial homeostasis and inflammation
Summary Immune-epithelial interactions are essential for intestinal homeostasis, yet organoid monocultures lack immune components and fail to model how immune cells shape epithelial identity. Here, we establish a macrophage-organoid co-culture integrating bone marrow-derived macrophages (BMDMs) into the intestinal nich...
Lisa Tonini, Tae‐Baek Lee, Eunju Jang et al.
· Stem Cell Reports · 0 citations