Fabrication and characterization of rutin-loaded liquid crystalline nanoparticles with in vitro anti-inflammatory and antitumor activities
ABSTRACT A rutin-loaded liquid crystalline nanoparticle (R-LCNP) formulation was developed using glyceryl monooleate and Poloxamer 407 by high-pressure homogenization to improve the solubility and biological performance of rutin. The optimized R-LCNP-2 dispersion showed a mean particle size of 176.1 ± 4.5 nm, a polydis...