Deubiquitination of ME1 by OTUD7B promotes aerobic glycolysis of esophageal cancer.
Esophageal cancer (EC) is among the most prevalent malignancies worldwide. Malic enzyme 1 (ME1), which catalyzes the oxidative decarboxylation of malate to pyruvate, contributes to the Warburg effect (aerobic glycolysis) and plays a pivotal role in the progression of tumor growth. Nevertheless, the functional contribut...