Loc Xuan Le

Anti-ferroptotic lignan glycosides from Zanthoxylum avicennae : Isolation, structural characterization, and mechanistic evaluation

Introduction: Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, has been implicated in various liver diseases. Small molecules that counteract ferroptosis remain largely restricted to a few synthetic scaffolds, leaving natural products an underexplored source. Zanthoxylum avicennae (Lam.)...