Lanthanide Metal-Organic Frameworks Enable Target-Triggered CRISPR-Cas12a Activator Release for Ultrasensitive Non-nucleic Acid Biomarker Detection.
A modular fluorescence signal transduction platform integrating aptamer-functionalized magnetic beads, lanthanide metal-organic frameworks, and CRISPR-Cas12a-mediated collateral cleavage amplification for sensitive cTnI detection, providing a universal strategy to expand CRISPR-Cas systems toward non-nucleic acid targe...