Long Zheng

Myricetin alleviates sepsis-induced endothelial hyperpermeability by inhibiting pyroptosis through the suppression of PAR1.

Dysfunction of the vascular endothelial barrier is a pivotal event in the pathogenesis of sepsis-induced multiple organ dysfunction syndrome (MODS). Myricetin (MYR), a naturally occurring flavonoid compound with diverse biological activities, has not been previously reported for its role and mechanism in septic vascula...