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Author

Loren B. Weidenhammer

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Open access Sep 2026

SERINC2-mediated phosphatidylserine remodeling activates protrusion-localized AXL signaling to promote brain metastasis

SUMMARY Cell protrusions (CPs) promote metastasis by coordinating cell invasion, matrix remodeling, and communication with the microenvironment. The receptor tyrosine kinase AXL, activated in brain-tropic metastatic cancers, frequently localizes to CPs. The metabolic cues regulating CP biogenesis and AXL activation rem...

Zhi-Bo Yan, Maja Beus, Zhan-Nan Han et al. · 0 citations

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