Recent data published in Cell demonstrate that a Cu 2+ -dependent form of regulated cell death (RCD) commonly known as cuproptosis is immunogenic, resulting in the emission of damage-associated molecular patterns (DAMPs) by malignant cells and the initiation of an adaptive anticancer immune response that not only ampli...
Lorenzo Galluzzi, O. Kepp, G. Kroemer· Signal Transduction and Targ...· 0 citations
Nicotinamide adenine dinucleotide (NAD) occupies a privileged position at the intersection of cellular bioenergetics, redox homeostasis, and signal transduction. Beyond its canonical role in ATP synthesis, NAD serves as an obligate cofactor for enzymes including poly(ADP-ribose) polymerases (PARPs), sirtuins, and CD38,...
Leire Arrizabalaga, Laura Santambrogio, G. Kroemer et al.· Cell Metabolism· 0 citations
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