Lorenzo Tomassini

Mitochondrial dysfunction as a metabolic checkpoint of immunotherapy response in colorectal cancer

Immunotherapy has markedly improved outcomes across multiple cancer types; however, colorectal cancer (CRC) remains largely refractory, with meaningful responses mostly restricted to tumors harboring deficient mismatch repair and high microsatellite instability (dMMR/MSI-H), which represent only a small fraction of CRC...