Open access
Jul 2026
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing.
Histone post-translational modifications are fundamental to genome regulation, yet dissecting the functions of individual histone marks in mammals remains challenging due to the presence of multiple histone gene copies. Here we develop a high-throughput clustered regularly interspaced short palindromic repeats (CRISPR)...
Daniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat et al.
· Nature Genetics · 0 citations