Author

Lu Chen

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Open access Aug 2026

Maternal PAN2 selectively maintains mRNA Poly(A) tail homeostasis to regulate RNA degradation during oocyte-to-early embryo transition in mice.

This study establishes maternal PAN2 as a critical regulator of poly(A) tail homeostasis, ensuring timely maternal mRNA clearance and proper ZGA, highlighting the stage-specific and tail-composition-dependent functions of the deadenylase cascade during the maternal-to-zygotic transition.

Xuan Wu, Hua Zhang, Yu-Ke Wu et al. · Science Bulletin · 0 citations

Open access Aug 2026

The RNA ac4C writer NAT10-dependent post-transcriptional regulations are prerequisites for zygotic splicing activation in mouse

It is demonstrated that the RNA ac 4 C writer NAT10 is essential for the post-transcriptional regulation of mouse zygotic splicing activation and provide valuable view for further exploration of the epigenetic mechanism during maternal-to-zygotic transition.

Wen-Jing Wang, Yu-Ke Wu, Yun-Wen Wu et al. · Cell Death & Disease · 0 citations