Author

Lu Chen

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Open access Sep 2026

A scalable, high-throughput glue perturbation screening platform for molecular glue discovery

Summary The discovery of molecular glue degraders (MGDs) is undergoing a paradigm shift from serendipitous discovery toward empirical design. However, efficiently prioritizing active leads from synthetic libraries while simultaneously confirming their E3 dependency remains a formidable challenge. In this study, we intr...

Di-Yun Huang, Ze-Yu Shuang, Lu Chen et al. · iScience · 0 citations

Jul 2026

Selective and Potent First-in-Class CRBN-Dependent Molecular Glue Degraders of WW Domain-Binding Protein 4.

Targeted protein degradation via molecular glues represents a powerful modality for modulating "undruggable" proteins. Herein, through proteomic profiling of a CRBN-binding library and rigorous structure-activity relationship (SAR) refinement, we report the discovery of dWBP4-1: a first-in-class, highly selective, CRBN...

Yu-Hang Liu, Lu Chen, Bo Peng et al. · Angewandte Chemie · 0 citations