Author

Lu-Jun Yin

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Sep 2026

Repurposing GS-441524 to inhibit biofilm formation and virulence of Bacillus cereus

Abstract Bacillus cereus is a resilient foodborne pathogen, with biofilm formation and virulence regulated by quorum sensing (QS). This study evaluates GS-441524, the active metabolite of remdesivir, as an anti-virulence agent against B. cereus. At sub-inhibitory concentrations, GS-441524 dose-dependently reduced prote...

Kai-Zhong Xu, Di Meng, Lu-Jun Yin et al. · Biofouling (Print) · 0 citations

Jul 2026

Transcriptomic Insights into Casein-Driven Adaptive Evolution of Burkholderia thailandensis: Implications for Biofilm Formation and Antibiotic Susceptibility.

It is demonstrated that casein-driven evolution selects for social 'cheaters' that conserve energy by downregulating costly virulence determinants, revealing a fundamental virulence-fitness trade-off.

Kai-Zhong Xu, Lu-Jun Yin, Zhi-Wen Ding et al. · Microbial Pathogenesis · 0 citations