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Author

Lu Kuang

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Review Open access Sep 2026

Research Progress on Signaling Pathways in Breast Cancer Bone Metastasis

Breast cancer (BC) has become the most commonly diagnosed malignant tumor among women worldwide, with approximately 70% of patients with advanced BC developing bone metastases. These metastases trigger bone destruction and skeletal-related events (SREs) and significantly reduce patient survival. In recent years, resear...

Yun-Hong Li, Tian-Qin Li, Feng-Liang-Feng Liang et al. · 0 citations
Open access Sep 2026

α-Tocopherol rescues lipid-induced impairment of autophagy via mTOR/ULK1 signaling in macrophages.

In vitro findings suggest that α-TOC reduces lipid accumulation and inhibits foam cell formation in macrophages by enhancing autophagic activity in association with reduced mTOR phosphorylation and increased ULK1 Ser555 phosphorylation.

Lu Kuang, Limei Wu, Zeng-Hui Liu et al. · 0 citations

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