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Review Open access Oct 2026

The CD160–HVEM axis at the crossroads of tolerance and immunity: lessons from cancer for autoimmunity and transplantation

The clinical success of immune checkpoint blockade (ICB) in oncology has validated the existence of molecular brakes that restrain T-cell immunity. While releasing these brakes unleashes antitumour responses, their physiological role is to maintain self-tolerance. This review explores the reciprocal paradigm of the...

Shu-Lin Sun, Lu-Lin Ma · 0 citations

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