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Author

Lu-Ming Sun

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Oct 2026

Maleimide-Thiol Conjugation Enables the Optimization of 68Ga-Labeled CAIX Targeting PET Probes.

Carbonic anhydrase IX (CAIX) is a well-established biomarker of tumor hypoxia and an attractive target for molecular imaging. Despite the development of small-molecule CAIX-targeting positron emission tomography (PET) probes, most exhibit high normal-organ uptake and suboptimal tumor-to-background contrast. Moreover, t...

Yong-Hao Li, Ai-Yan Ji, Bo-Yu Tan et al. · 0 citations
Oct 2026

Design and Biological Evaluation of FAP-Man, a Mannosylated FAP-Targeted Radioglycopeptide for Tumor Imaging and Radionuclide Therapy

Fibroblast activation protein (FAP) is an attractive target for radiotheranostic development because of its abundant expression in tumor-associated fibroblasts and limited distribution in normal tissues. Here, we developed FAP-Man, a mannosylated FAP-targeted radioglycopeptide based on the FAP-2286 scaffold, to optim...

Miao-Miao Song, En-Tao Liu, Rui Cao et al. · 0 citations

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