Author

Lu Ren

2 papers indexed here

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Review Open access Aug 2026

The APOE4-estrogen-microglia axis in perimenopausal cognitive changes: mechanisms and therapeutic implications

A precision medicine framework for preventing or delaying neurodegenerative progression in high-risk perimenopausal women is proposed, centered on the APOE4-estrogen deficiency-microglia axis.

Liu-Qing Shi, Chun-Tong Zhou, Huan Han et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer’s disease models

Introduction Icariside II (ICS II), a major bioactive flavonoid metabolite from Epimedium, has been reported to exert neuroprotective effects, but its role in regulating mitochondrial dysfunction-related neuronal injury in Alzheimer’s disease (AD) has not been fully clarified. Methods In this study, we administered ICS...

Si-Yu Shan, Jia-Ming Bai, Yu Tian et al. · Frontiers in Pharmacology · 0 citations