Author

L. Du

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Aug 2026

A targetable ALDH3A2-NRF2 axis mediates KEAP1-mutant tumour development via ferroptosis inhibition.

A novel NRF2 regulatory pathway is revealed and ALDH3A2 is suggested as a promising druggable target for KEAP1-mutant tumours by performing an aldehyde dehydrogenase 3 family shRNA screen.

Li Yang, Xiao Zhuang, Jing Han et al. · Cell Death and Differentiati... · 0 citations

Open access Aug 2026

Spatial remodeling of inflammatory niches drives stemness acquisition and malignant transformation during early gastric tumorigenesis.

This study uncovers spatially organized inflammatory niches that precede and promote early gastric tumorigenesis by linking precancerous inflammation to stemness acquisition through spatial microenvironmental remodeling, highlighting a critical, targetable window for early intervention in GC.

Tiantian Du, Hui-Ru Gao, Jie Gao et al. · Chinese Medical Journal · 0 citations