Lu-Yu Yang

Spatial multi-omics enables single-cell transcriptome–metabolome inference

Joint single-cell transcriptomic–metabolomic profiling remains technically intractable. Here we present CHIMERA (Cell-level Hybrid Inference of Metabolome Embedded on RNA Atlas), a data-driven framework that learns transcriptome-to-metabolome mappings from spatially paired multi-omics data and transfers them to unpaire...