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Lu-Zheng Wang

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Aug 2026

Oncogenic DHX15 mutation enhances mitochondrial metabolism and sustains leukemia stemness.

Functional analysis demonstrates that DHX15R222G cooperates with AML1-ETO fusion protein to enhance AML leukemia stem cell (LSC) activity and promote resistance to standard chemotherapy, and underscores the pivotal role of oncogenic DHX15 mutations in regulating AML LSC activity.

Qi-Long Li, Pei-Qi Xing, Jin Xu et al. · 0 citations

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