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Author

Lucia Pertierra

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Open access Sep 2026

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study.

BACKGROUND As individuals with Down syndrome age, they face high risks of Alzheimer's disease and epilepsy. With symptomatic Alzheimer's disease, late-onset myoclonic epilepsy in Down syndrome (LOMEDS) often emerges. We aimed to examine how epilepsy develops in Down syndrome, its timing relative to Alzheimer's disease...

Lucía Maure-Blesa, M. Carmona-Iragui, I. Barroeta et al. · 1 citation
Open access Jul 2026

CSF and plasma tau biomarkers in the Down syndrome–Alzheimer’s disease continuum

These findings highlight the complementary roles of CSF and plasma tau biomarkers in tracking disease progression: CSF biomarkers capture early pathological changes, whereas plasma biomarkers more effectively reflect disease progression within symptomatic stages.

J. Arranz, J. Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt et al. · 1 citation

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