Author

Luigi Marchionni

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Open access Sep 2026

Integrated signatures define mutational processes in prostate cancer.

Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology1. Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-base substitution, insertion...

A. Gruber, A. Olsen, Bárbara Hernando et al. · Nature · 1 citation

Open access Aug 2026

Common germline polymorphisms and somatic cancer mutations exhibit non-random positional overlap across the human genome

Germline and somatic mutations have traditionally been studied independently because they arise in distinct biological contexts and are shaped by different selective pressures. Despite these differences, both originate from the same molecular processes of DNA damage, replication error, and DNA repair. Yet this separati...

Thais Silva Tavares, Daniela Souza Lima Barbosa, R. P. de Souza et al. · bioRxiv · 0 citations