Insights into the molecular recognition of the second PDZ domain of ZO1 by coronavirus Envelope-derived peptides.
The Envelope (E) protein, one of the structural proteins encoded by coronavirus (CoV) genome, is involved in multiple processes of the virus life cycle and directly related to the pathogenesis process. The C-terminus of E contains an important virulence factor, a PDZ domain binding motif (PBM), whose deletion or modifi...