Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis.
BACKGROUND Atopic dermatitis (AD) is primarily driven by a Type 2 immune response, with T helper (TH2) cells producing IL-4 and IL-13, thereby promoting inflammation, itch, and a compromised skin barrier. Yet, the spatial organization of pathogenic immune cells and their interactions with stromal and epithelial compart...